Michael Givskov Selected Research

bis(3',5')-cyclic diguanylic acid

1/2021	Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms.
1/2021	Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants.
7/2015	The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP.
8/2013	Clearance of Pseudomonas aeruginosa foreign-body biofilm infections through reduction of the cyclic Di-GMP level in the bacteria.
8/2012	Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa.

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Michael Givskov Research Topics

Disease

45	Infections 01/2021 - 05/2001
13	Persistent Infection 02/2016 - 02/2005
8	Cystic Fibrosis (Mucoviscidosis) 12/2020 - 04/2004
6	Bacterial Infections (Bacterial Infection) 01/2021 - 10/2009
6	Inflammation (Inflammations) 01/2021 - 02/2009
5	Wounds and Injuries (Trauma) 07/2015 - 08/2007
3	Keratitis 01/2018 - 01/2016
3	Leg Ulcer 05/2011 - 12/2009
2	Starvation 01/2021 - 01/2013
2	Pneumonia (Pneumonitis) 12/2020 - 11/2014
2	Sepsis (Septicemia) 01/2019 - 04/2018
2	Soft Tissue Infections 04/2018 - 08/2014
2	Pseudomonas Infections 01/2018 - 04/2004
2	ST Elevation Myocardial Infarction 01/2016 - 01/2015
2	Foreign Bodies (Foreign Body) 08/2013 - 05/2012
1	Cardiac Arrhythmias (Arrythmia) 01/2022
1	Periodontitis 01/2021
1	Endocarditis 01/2019
1	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 01/2019
1	Neoplasms (Cancer) 01/2019
1	Bacteremia 04/2018
1	Atherosclerosis 01/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Atherosclerotic Plaque (Atheroma) 09/2015
1	Transient Ischemic Attack 09/2015
1	Stroke (Strokes) 09/2015
1	Urinary Tract Infections (Urinary Tract Infection) 08/2015
1	Non-ST Elevated Myocardial Infarction 01/2015
1	Stable Angina 01/2015
1	Unstable Angina 01/2015

Drug/Important Bio-Agent (IBA)

34	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 04/2004
5	bis(3',5')-cyclic diguanylic acidIBA 01/2021 - 08/2012
5	Pharmaceutical PreparationsIBA 01/2018 - 08/2003
5	Virulence Factors (Pathogenicity Factors)IBA 07/2015 - 10/2007
5	AlginatesIBA 06/2009 - 04/2005
4	Tobramycin (Nebcin)FDA LinkGeneric 05/2012 - 12/2005
3	DNA (Deoxyribonucleic Acid)IBA 10/2017 - 05/2013
3	CytokinesIBA 01/2017 - 12/2009
3	16S Ribosomal RNAIBA 01/2015 - 01/2010
3	Peptide Nucleic AcidsIBA 05/2011 - 08/2008
2	EnzymesIBA 01/2022 - 01/2013
2	purineIBA 01/2021 - 01/2013
2	polyacrylamideIBA 04/2014 - 10/2009
2	IronIBA 01/2013 - 01/2011
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 12/2009 - 02/2009
2	Immunoglobulin G (IgG)IBA 01/2004 - 05/2001
1	Topoisomerase InhibitorsIBA 01/2022
1	DNA Topoisomerase IV (Topoisomerase IV)IBA 01/2022
1	4-nitrobenzylthioinosineIBA 01/2022
1	DNA GyraseIBA 01/2022
1	Potassium Channels (Potassium Channel)IBA 01/2022
1	NucleotidesIBA 01/2021
1	Amino Acids FDA Link 01/2021
1	CarbonIBA 01/2021
1	Oxygen (Dioxygen)IBA 01/2021
1	MutagensIBA 01/2021
1	Green Fluorescent ProteinsIBA 01/2021
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2021
1	Peptidoglycan (Murein)IBA 01/2021
1	Interleukin-2 (IL2)IBA 12/2020
1	cyclic diadenosine phosphateIBA 01/2019
1	Immunologic Adjuvants (Immunologic Adjuvant)IBA 05/2018
1	cytotoxic necrotizing factor type 1IBA 05/2018
1	Bacterial Proteins (Bacterial Protein)IBA 05/2018
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 05/2018
1	Enterotoxins (Enterotoxin)IBA 04/2018
1	Peptides (Polypeptides)IBA 04/2018
1	MacrolidesIBA 01/2018
1	Carbapenems (Carbapenem Antibiotics)IBA 01/2018
1	Cisplatin (Platino)FDA LinkGeneric 01/2018
1	Amikacin (A.M.K)FDA LinkGeneric 10/2017
1	Gatifloxacin (Zymar)FDA Link 10/2017
1	besifloxacin FDA Link 10/2017
1	CholesterolIBA 01/2017
1	Colistin (Coly-Mycin)FDA Link 01/2017
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2016
1	Bacterial DNAIBA 01/2016
1	OligosaccharidesIBA 08/2015
1	Acetic Acid (Vinegar)FDA LinkGeneric 07/2015
1	GoldIBA 06/2015
1	CeroidIBA 06/2015
1	HemosiderinIBA 06/2015
1	Type III Secretion SystemsIBA 11/2014
1	Methicillin (Metin)FDA Link 08/2014
1	Fusidic Acid (Fucithalmic)IBA 08/2014
1	GelsIBA 04/2014
1	Hyaluronic Acid (Hyaluronan)IBA 04/2014
1	Hydroxyl RadicalIBA 04/2014
1	ApatitesIBA 04/2014
1	CalciumIBA 04/2014
1	HydrogelsIBA 04/2014
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2014
1	Lipase (Acid Lipase)FDA Link 01/2014

Therapy/Procedure

6	Therapeutics 01/2021 - 04/2004
2	Lasers (Laser) 05/2011 - 12/2009
1	Slit Lamp 10/2017
1	Drug Therapy (Chemotherapy) 10/2017
1	Percutaneous Coronary Intervention 01/2016
1	Endarterectomy (Thromboendarterectomy) 09/2015
1	Microspheres (Microsphere) 04/2014